If you’ve started taking Ozempic (semaglutide) for diabetes or weight loss, you may have heard rumors about side effects — including the question:
👉 “Can Ozempic cause urinary tract infections (UTIs)?”
The short answer is no — current medical evidence shows that Ozempic does not increase the risk of UTI.
Let’s break down what the research says in simple terms.
Ozempic belongs to a class of medications called GLP-1 receptor agonists. These drugs mimic a natural hormone your body makes, which helps lower blood sugar, reduce appetite, and support weight loss.
They’re different from another popular diabetes drug class called SGLT2 inhibitors (such as Jardiance or Farxiga). SGLT2 inhibitors work by helping the kidneys remove extra sugar through urine — and that process can sometimes increase the risk of urinary and genital infections.
Because Ozempic doesn’t work through the kidneys, it does not increase sugar in the urine and therefore doesn’t increase UTI risk.
Several major studies have looked specifically at whether GLP-1 drugs like semaglutide cause urinary tract infections — and the answer has been consistently no.
A 2025 Danish study compared over 100,000 people with diabetes who started either GLP-1 receptor agonists or SGLT2 inhibitors.
After one year:
That’s almost identical — showing no extra UTI risk for those taking Ozempic (risk ratio 0.98, 95% CI 0.94–1.03)【1】.
A 2025 analysis of worldwide drug safety reports also found no pharmacovigilance signal — meaning no increase in UTI reports — for GLP-1 drugs like Ozempic, while SGLT2 inhibitors showed a strong association with urinary infections【2】.
In plain language: millions of patients take semaglutide, and the data doesn’t show UTIs happening more often than normal.
If a drug commonly causes a side effect, the FDA lists it in the prescribing information.
Ozempic’s official FDA label includes nausea, vomiting, diarrhea, and constipation — but not urinary tract infection【3】.
Across dozens of clinical trials, researchers also found no increase in UTI risk with semaglutide.
Independent scientific reviews pooling data from thousands of patients confirmed that Ozempic’s main side effects are gastrointestinal, not infections.
For example, studies published in Frontiers in Endocrinology【4】, Current Medical Research and Opinion【5】, and the International Journal of Molecular Sciences【6】 all found no significant increase in urinary or genital infections in people taking semaglutide.
UTIs are one of the most common infections, especially in women, and they can be painful and disruptive.
It’s natural to wonder whether a new medication might make them more likely.
But with Ozempic, you can rest assured: the evidence is clear and consistent — it doesn’t raise your risk of getting a UTI.
If you do experience UTI symptoms (burning, urgency, cloudy urine), it’s likely unrelated to your medication and should be treated promptly.
At UTIRx.com, our team of urologists provides same-day online prescriptions for uncomplicated urinary tract infections. You can start treatment quickly — without waiting for an appointment or visiting urgent care.
If you’re taking Ozempic for diabetes or weight loss, you can continue safely without worrying about urinary tract infections.
Your UTI risk depends on many factors — hydration, hygiene, sexual activity, and medical history — not your Ozempic use.
If you ever feel symptoms coming on, UTIRx.com is here to help. Our board-certified urologists can review your symptoms and send treatment to your local pharmacy the same day — no video call required.
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